Ruby, Flesh & Heart

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- Stone Fruit -

Ruby Cube Lyrics provided by SongLyrics. Note: When you embed the widget in your site, it will match your site's styles CSS. This is just a preview! Cannot annotate a non-flat selection.

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Flesh [Part 4] for xXx Ruby Fh xXx

Song Lyrics. Use this plum for fresh eating or add to salads, ice cream, and pies. Developed in by Luther Burbank this deep ruby red plum has a thin skin that pops when you bit into it! It is sweet with low acid and the flesh is firm and red-orange throughout. Pair this plum with lamb, pork or a mild fresh cheese.

They also work well in your favorite pie or tart. Store plums in the refrigerator up to one week or better yet eat them straight away!

There are red-fleshed and white-fleshed cvs. Red flesh is due to lycopene and carotenoid pigments. Most of today's commercial cultivars are selections or mutations from earlier ones, which were replaced gradually with newer ones. Consumers prefer red-fleshed seedless fruits, so white grapefruits are slowly being replaced.

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These are mutations limb sports of Thompson pink, which is a limb-sport of Marsh seedless grapefruit. Red Blush and Ruby Red are red-fleshed grapefruit with almost identical fruit and tree characters and selected in Texas. It is high yielding, has fewer seeds, a thinner rind, and a higher TSS.

Ray Ruby has even deeper red flesh than Henderson. Ray Ruby is a mutation of Ruby Red.

Rio Red is a seedling selection from Ruby Red. Flesh color of Rio Red is deeper than Ray Ruby with higher yields. In South Africa, Rio Red matures when most other grapefruits are harvested. Peel color is similar to Ray Ruby and internal color is similar to Star Ruby.

In Ray Ruby, Flame, and Rio Red, deep red color of flesh persists longer, hence marketing can be extended. Fruits of these cvs develop red color on rind and flesh even in tropical warm areas.

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Smaller fruit size, seedless, matures 6 weeks before Marsh seedless. Fruit has good flavor, but this cv. Fruits are borne inside canopies, so there is less damage due to frost.

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Fruits are white fleshed, matures from November to February, seedless, light yellow pulp, vesicles are juicy. Alex C. Chin, Leland B. Baskin, in Therapeutic Drug Monitoring , Grapefruit is a popular dietary component among North Americans. The active chemical compounds in grapefruit include flavones, isoflavones, flavonols, furanocoumarins and anthocyanidin, which have been found to have antioxidant, anti-inflammatory and antimicrobial activities. The flavonoids of interest include naringin, quercetin and kaempferol.

It is hydrolyzed to naringenin by intestinal flora. Furanocoumarins, such as bergomattin, and flavonoids, such as naringin, may play the most active roles in the effects of grapefruit on plasma drug levels [45—49]. In light of its popularity, grapefruit has been associated with increased bioavailability of many drugs. Clinical studies have found that grapefruit increases the oral bioavailability of the calcium channel blockers felodipine, nifedipine and pranidipine [46, 50, 51].

Later studies found that the increase in felodipine and nifedipine may not be due to naringin or quercetin [52, 53] , but instead to inter-individual differences in naringin metabolism by intestinal flora [54].

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The interaction between grapefruit juice and increase in plasma levels of calcium channel blockers such as felodipine and amlodipine was clinically significant, since patients experienced increased heart rate, decreased diastolic blood pressure, and headaches [55, 56]. Grapefruit juice also may affect cyclosporine pharmacokinetics in transplant patients [58—60] and patients with autoimmune disease [61]. Slight inhibition of cyclosporine metabolism, but not prednisone, for a brief period just after grapefruit ingestion, likely due to inhibition of intestinal cytochrome P enzymes, has been reported [58].

Initial observations of grapefruit juice-induced increase in felodipine may have depended on the route of administration where drug levels were affected by oral intake as compared to intravenous injection [62]. Grapefruit juice increases the plasma levels of many drugs which are likely metabolized by intestinal CYP3A4 activity Table Furthermore, grapefruit juice did not affect metabolism of quinine, which is mainly metabolized by CYP3A4 in the liver, thus supporting the view that grapefruit affects intestinal cytochrome P [63].

‘Ruby: The King of Gems’ by Joanna Hardy

However, while a single intake of grapefruit juice may alter intestinal CYP3A4 [55, 62, 64] , further investigations have found that repeated consumption may proceed to inhibit hepatic CYP3A4 [65, 66]. In contrast, grapefruit juice did not affect the pharmacokinetics or hemodynamics, such as elevated heart rate or blood pressure, of caffeine [67] , which is a CYP1A2 substrate.

TABLE Drugs whose Bioavailability is Increased by Grapefruit Juice.

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  • While inhibition of CYP3A4 delays drug metabolism and consequently increases plasma levels of affected drugs, grapefruit juice may also affect drug transport. In regard to drug efflux, grapefruit juice did not significantly affect digoxin pharmacokinetics, and thus is unlikely to be an important inhibitor of P-gp function [68]. However, one in vitro study has demonstrated impaired uptake of the antihistamine fexofenadine in epithelial cells transfected with OATP1A2 [69]. The possible role of grapefruit juice as an inhibitor of OATP was further extended in clinical studies [70—72].

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